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BRAIN Publication-derived
Cerebral Organoids with Single-Cell Profiling
No SOP yet
Source Camp et al. · Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany · 10.1073/pnas.1520760112
Authors: Camp JG, Badsha F, Florio M, Kanton S, Gerber T, Wilsch-Bräuninger M, Lewitus E, Sykes A, Hebers WB, Lancaster MA, Knoblich JA, Settlings R, Treutlein B Duration: 75 days Cell source: Human iPSC / Human Fetal Tissue (comparison)
Abstract
Camp et al. performed the first single-cell RNA-sequencing analysis of cerebral organoids, comparing transcriptional profiles to human fetal neocortex at 12-13 post-conception weeks. The study confirmed that organoid-derived neural progenitors and neurons recapitulate key gene expression programs of fetal cortical development, establishing scRNA-seq as a critical quality control benchmark.
Cell source
Human iPSC / Human Fetal Tissue (comparison)
Application
Organoid Transcriptomic Benchmarking
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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