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BRAIN Publication-derived
Brain Reference Datasets for Developmental Studies
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Source Pollen et al. · University of California San Francisco (UCSF), San Francisco, CA, USA · 10.1016/j.cell.2019.01.017
Authors: Pollen AA, Bhaduri A, Andrews MG, Nowakowski TJ, Meyerson OS, Mostajo-Radji MA, Di Lullo E, Alvarado B, Bedolli M, Dougherty ML, Fiddes IT, Kronenberg ZN, Shuga J, Ber AA, Cadwell CR, Cebrian-Silla A, Diber O, Geschwind DH, Eichler EE, Haussler D, Kriegstein AR Duration: 120 days Cell source: Human iPSC / Chimpanzee iPSC / Macaque iPSC
Abstract
Pollen et al. established cerebral organoids from human, chimpanzee, and macaque iPSCs to identify human-specific features of brain development through cross-species single-cell RNA-sequencing. The study revealed an expanded population of outer radial glia and human-specific gene expression programs in cortical progenitors, positioning organoids as a model system for studying human brain evolution.
Cell source
Human iPSC / Chimpanzee iPSC / Macaque iPSC
Application
Human Brain Evolution Research
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OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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