BRAIN Publication-derived

Specific Brain Evolution

Source Pollen et al. · University of California San Francisco (UCSF), San Francisco, CA, USA · 10.1016/j.cell.2019.01.017

👤 Pollen AA, Bhaduri A, Andrews MG, Nowakowski TJ, Meyerson OS, Mostajo-Radji MA, Di Lullo E, Alvarado B, Bedolli M, Dougherty ML, Fiddes IT, Kronenberg ZN, Shuga J, Ber AA, Cadwell CR, Cebrian-Silla A, Diber O, Geschwind DH, Eichler EE, Haussler D, Kriegstein AR ⏱ 57600 min 🧫 Human iPSC / Chimpanzee iPSC / Macaque iPSC

Abstract

Pollen et al. established cerebral organoids from human, chimpanzee, and macaque iPSCs to identify human-specific features of brain development through cross-species single-cell RNA-sequencing. The study revealed an expanded population of outer radial glia and human-specific gene expression programs in cortical progenitors, positioning organoids as a model system for studying human brain evolution.

Cell source

Human iPSC / Chimpanzee iPSC / Macaque iPSC

Application

Human Brain Evolution Research

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Pollen et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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