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BRAIN Publication-derived
Brain Organoids for Disease Modelling with Blood-Brain Barrier
No SOP yet
Source Pellegrini et al. · MRC Laboratory of Molecular Biology, Cambridge, UK · 10.1126/science.aaz5626
Authors: Pellegrini L, Bonfio C, Chadber J, Begber SA, Lancaster MA Duration: 45 days Cell source: Human iPSC / Human ESC
Abstract
Pellegrini et al. developed choroid plexus organoids from human iPSCs that self-organize into cystic structures producing cerebrospinal fluid-like fluid with selective barrier properties. Published in Science 2020, this Lancaster lab protocol enables modeling of the blood-CSF barrier for CNS drug delivery studies and investigation of choroid plexus-related pathologies.
Cell source
Human iPSC / Human ESC
Application
Blood-CSF Barrier Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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