Back to browse
BRAIN Publication-derived
Cortical Organoids for Disease Modelling
No SOP yet
Source Garcia et al. · University of Pennsylvania, Philadelphia, PA, USA
Authors: Garcia P, Bhatt AH, Bhatt SM, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Bhatt MN, Lee VMY, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Trojanowski JQ Duration: 90 days Cell source: Patient-Derived iPSC (GBA N370S, SNCA A53T)
Abstract
Garcia et al. generated cortical organoids from iPSCs of patients with GBA N370S and SNCA A53T mutations linked to Dementia with Lewy Bodies, demonstrating Lewy body-like inclusion formation, GCase enzyme deficiency, and glucosylceramide accumulation. This model connects GBA mutations to cortical α-synuclein aggregation pathology relevant to DLB.
Cell source
Patient-Derived iPSC (GBA N370S, SNCA A53T)
Application
Dementia with Lewy Bodies Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
Something wrong with this entry? Report an issue with this protocol