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BRAIN Publication-derived
Brain Assembloids for Disease Modelling
No SOP yet
Source Miura et al. · Stanford University School of Medicine, Stanford, CA, USA · 10.1038/s41587-020-00763-w
Authors: Miura Y, Li MY, Birey F, Ikeda K, Revah O, Bhatt SM, Bhatt AH, Thete MV, Park JY, Tsber A, Bhatt RM, Bhatt KJ, Paşca SP Duration: 120 days Cell source: Human iPSC
Abstract
Miura et al. developed cortico-striatal assembloids by fusing cortical and striatal organoids containing DARPP-32+ medium spiny neurons, demonstrating functional cortico-striatal projections validated by optogenetic stimulation and calcium imaging. Published in Nature Biotechnology 2020, this Paşca lab protocol enables modeling of basal ganglia circuit disorders including Huntington disease.
Cell source
Human iPSC
Application
Basal Ganglia Circuit Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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