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BRAIN Publication-derived
Brain Assembloids for Disease Modelling with Vasculature
No SOP yet
Source Cakir et al. · Yale University, New Haven, CT, USA · 10.1038/s41592-019-0586-5
Authors: Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Shin K, Niklason LE, Park IH Duration: 70 days Cell source: Human iPSC (+ ETV2-Inducible Endothelial Cells)
Abstract
Cakir et al. generated vascularized brain organoids by incorporating ETV2-inducible endothelial cells that form vessel-like networks expressing blood-brain barrier markers within cortical organoid tissue. This Nature Methods 2019 study addressed the critical organoid limitation of nutrient diffusion and necrotic core formation while providing a BBB model for drug delivery research.
Cell source
Human iPSC (+ ETV2-Inducible Endothelial Cells)
Application
Blood-Brain Barrier Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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