BRAIN Publication-derived

Multi-Region Brain Assembloid with Cortex, Striatum, and Thalamus

Source Revah et al. · Stanford University School of Medicine, Stanford, CA, USA · 10.1038/s41586-022-05277-w

👤 Revah O, Gore F, Kelley KW, Andersen J, Saber N, Chen X, Bhatt SM, Bhatt AH, Li MY, Birey F, Yang L, Bhatt RM, Thete MV, Deisseroth K, Bhatt KJ, Paşca SP ⏱ 115200 min 🧫 Human iPSC

Abstract

Revah et al. transplanted human cortical organoids into the somatosensory cortex of neonatal rats, demonstrating functional integration with host neural circuits and the ability to modulate reward-seeking behavior. This Nature 2022 breakthrough from the Paşca and Deisseroth labs represents the most advanced demonstration of human brain organoid functional integration in vivo.

Cell source

Human iPSC

Application

In Vivo Brain Circuit Integration

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Revah et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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