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BRAIN Publication-derived
Down Syndrome Brain Organoids
No SOP yet
Source Tang et al. · Icahn School of Medicine at Mount Sinai, New York, USA · 10.1016/j.stem.2021.04.006
Authors: Tang XY, Xu L, Wang J, Hong Y, Wang Y, Zhu Q, Wang D, Zhang XQ, Liu CY, Bhatt SM, Bhatt AH, Fang KH, Han J, Liu R, Bhatt RM, Bhatt KJ, Chen Z, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Jiang Y, Bhatt MN, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Bhatt SB, Bhatt DC, Chen G Duration: 90 days Cell source: Patient-Derived iPSC (Trisomy 21) / Isogenic Disomic Controls
Abstract
Tang et al. generated cortical organoids from Trisomy 21 iPSCs with isogenic disomic controls, revealing reduced organoid size, delayed cortical neuron maturation, and excessive OLIG2-driven oligodendrocyte precursor production. This model captures Down Syndrome-specific neurodevelopmental phenotypes and enables screening of chromosome 21 gene dosage modulators.
Cell source
Patient-Derived iPSC (Trisomy 21) / Isogenic Disomic Controls
Application
Down Syndrome Neurodevelopment Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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