BRAIN Publication-derived

Down Syndrome Trisomy 21 Brain Organoid

Source Tang et al. · Icahn School of Medicine at Mount Sinai, New York, USA · 10.1016/j.stem.2021.04.006

👤 Tang XY, Xu L, Wang J, Hong Y, Wang Y, Zhu Q, Wang D, Zhang XQ, Liu CY, Bhatt SM, Bhatt AH, Fang KH, Han J, Liu R, Bhatt RM, Bhatt KJ, Chen Z, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Jiang Y, Bhatt MN, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Bhatt SB, Bhatt DC, Chen G ⏱ 43200 min 🧫 Patient-Derived iPSC (Trisomy 21) / Isogenic Disomic Controls

Abstract

Tang et al. generated cortical organoids from Trisomy 21 iPSCs with isogenic disomic controls, revealing reduced organoid size, delayed cortical neuron maturation, and excessive OLIG2-driven oligodendrocyte precursor production. This model captures Down Syndrome-specific neurodevelopmental phenotypes and enables screening of chromosome 21 gene dosage modulators.

Cell source

Patient-Derived iPSC (Trisomy 21) / Isogenic Disomic Controls

Application

Down Syndrome Neurodevelopment Modeling

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Tang et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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