Microcephaly Mechanism
Source Garcez et al. · Federal University of Rio de Janeiro (UFRJ), Brazil
Abstract
Garcez et al. infected cerebral organoids with the Brazilian Zika virus strain, demonstrating a 40% reduction in organoid size due to neural progenitor cell death and depletion. Published during the 2016 Zika epidemic, this Science study provided critical mechanistic evidence linking ZIKV infection to congenital microcephaly through preferential neural progenitor destruction.
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Attribution
This SOP was authored by Organthis based on the published method in Garcez et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.
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