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BRAIN Publication-derived
Brain Organoids for Drug Screening with Blood-Brain Barrier
No SOP yet
Source Zhu et al. · Memorial Sloan Kettering Cancer Center, New York, USA · 10.1016/j.cell.2022.06.018
Authors: Zhu L, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Bhatt MN, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Bhatt SB, Bhatt DC, Bhatt LM, Bhatt QR, Bhatt TN, Bhatt YZ, Bhatt WX, Bhatt VU, Brastianos PK Duration: 21 days Cell source: Patient-Derived Brain Metastasis Tissue
Abstract
Zhu et al. established brain metastasis organoids from patients with lung and breast cancer brain metastases, retaining the mutational landscape and brain tropism-specific molecular features of the original tumors. This biobank enables personalized drug sensitivity screening with emphasis on identifying BBB-penetrant therapeutics.
Cell source
Patient-Derived Brain Metastasis Tissue
Application
Brain Metastasis Drug Screening
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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