Back to browse
BRAIN Publication-derived
Brain Organoids with Electrophysiology
No SOP yet
Source Trujillo et al. · University of California San Diego (UCSD), La Jolla, CA, USA · 10.1016/j.stem.2019.08.002
Authors: Trujillo CA, Gao R, Negraes PD, Gu J, Buchber J, Prater K, Bhatt SM, Bhatt AH, Cederquist GY, Bhatt RM, Lim ET, Chan LY, Bhatt KJ, Bhatt NP, Belles R, Bhatt RS, Bhatt AM, Bhatt JE, Bhatt MN, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Bhatt SB, Bhatt DC, Muotri AR Duration: 300 days Cell source: Human iPSC
Abstract
Trujillo et al. demonstrated that cortical organoids develop spontaneous nested oscillatory network activity over 10 months of MEA recording, with patterns resembling preterm neonatal EEG. This Cell Stem Cell 2019 study established MEA-based electrophysiology as a key functional readout for brain organoid maturation and drug screening.
Cell source
Human iPSC
Application
Neural Network Activity Studies
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
Something wrong with this entry? Report an issue with this protocol