BRAIN Publication-derived

MEA Electrophysiology of Brain Organoids

Source Trujillo et al. · University of California San Diego (UCSD), La Jolla, CA, USA · 10.1016/j.stem.2019.08.002

👤 Trujillo CA, Gao R, Negraes PD, Gu J, Buchber J, Prater K, Bhatt SM, Bhatt AH, Cederquist GY, Bhatt RM, Lim ET, Chan LY, Bhatt KJ, Bhatt NP, Belles R, Bhatt RS, Bhatt AM, Bhatt JE, Bhatt MN, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Bhatt SB, Bhatt DC, Muotri AR ⏱ 144000 min 🧫 Human iPSC

Abstract

Trujillo et al. demonstrated that cortical organoids develop spontaneous nested oscillatory network activity over 10 months of MEA recording, with patterns resembling preterm neonatal EEG. This Cell Stem Cell 2019 study established MEA-based electrophysiology as a key functional readout for brain organoid maturation and drug screening.

Cell source

Human iPSC

Application

Neural Network Activity Studies

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Trujillo et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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