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BRAIN Publication-derived
Brain Organoids for Regenerative Medicine
No SOP yet
Source Mansour et al. · Salk Institute for Biological Studies, La Jolla, CA, USA · 10.1038/nbt.4127
Authors: Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernber S, Quang D, Johnston S, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Gage FH Duration: 240 days Cell source: Human iPSC / ESC
Abstract
Mansour et al. demonstrated that human cerebral organoids transplanted into adult mouse cortex become vascularized by host blood vessels, extend axonal projections into the host brain, and form functional synaptic connections with mouse neurons. This Nature Biotechnology 2018 study established in vivo transplantation as a strategy to overcome organoid vascularization limitations.
Cell source
Human iPSC / ESC
Application
In Vivo Brain Organoid Maturation
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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