BRAIN Publication-derived

Human Brain Organoid Transplantation into Adult Mouse Brain

Source Mansour et al. · Salk Institute for Biological Studies, La Jolla, CA, USA · 10.1038/nbt.4127

👤 Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernber S, Quang D, Johnston S, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Gage FH ⏱ 115200 min 🧫 Human iPSC / ESC

Abstract

Mansour et al. demonstrated that human cerebral organoids transplanted into adult mouse cortex become vascularized by host blood vessels, extend axonal projections into the host brain, and form functional synaptic connections with mouse neurons. This Nature Biotechnology 2018 study established in vivo transplantation as a strategy to overcome organoid vascularization limitations.

Cell source

Human iPSC / ESC

Application

In Vivo Brain Organoid Maturation

Full SOP

🔬

Create a free account to access this protocol

Join OrganMatch to unlock step-by-step procedures, reagent concentrations, QC checklists, and downloadable batch record templates.

Create free account

Already registered? Log in

Attribution

This SOP was authored by Organthis based on the published method in Mansour et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

This wording is awaiting legal review.

Something wrong with this entry? Report an issue with this protocol

Need a commercial licence?

Use this protocol in your therapeutic or diagnostic pipeline.

Request Commercial Licence