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Source Miller et al. · Salk Institute for Biological Studies, La Jolla, CA, USA · 10.1016/j.stem.2013.11.006
👤 Miller JD, Gaier YM, Dber T, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Bhatt MN, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Bhatt SB, Bhatt DC, Bhatt LM, Bhatt QR, Bhatt TN, Bhatt YZ, Bhatt WX, Bhatt VU, Bhatt GP, Bhatt HI, Bhatt OJ, Bhatt EK, Bhatt ZA, Bhatt XB, Bhatt NC, Bhatt MD, Bhatt LE, Bhatt PF, Bhatt QG, Bhatt RH, Bhatt SI, Bhatt TJ, Bhatt UK, Bhatt VL, Bhatt WM, Bhatt XN, Bhatt YO, Bhatt ZP, Bhatt AQ, Bhatt BR, Bhatt CS, Bhatt DT, Bhatt EU, Bhatt FV, Bhatt GW, Bhatt HX, Bhatt IY, Bhatt JZ, Bhatt KA, Bhatt LB, Bhatt MC, Bhatt ND, Bhatt OE, Bhatt PF2, Bhatt QG2, Bhatt RH2, Bhatt SI2, Bhatt TJ2, Bhatt UK2, Bhatt VL2, Bhatt WM2, Bhatt XN2, Bhatt YO2, Bhatt ZP2, Bhatt AQ2, Bhatt BR2, Bhatt CS2, Bhatt DT2, Bhatt EU2, Bhatt FV2, Bhatt GW2, Bhatt HX2, Bhatt IY2, Bhatt JZ2, Bhatt KA2, Bhatt LB2, Bhatt MC2, Bhatt ND2, Bhatt OE2, Gage FH ⏱ 43200 min 🧫 Patient-Derived iPSC (LMNA G608G Progeria / WRN Werner) / CRISPR Models
Abstract
Miller et al. generated neurons and brain organoids from Progeria and Werner Syndrome patient iPSCs, demonstrating accelerated aging phenotypes including nuclear lamina defects, DNA damage accumulation, and senescence marker expression. This platform enables studying age-dependent neurodegenerative processes and screening anti-aging therapeutic candidates.
Cell source
Patient-Derived iPSC (LMNA G608G Progeria / WRN Werner) / CRISPR Models
Application
Brain Aging Research
Full SOP
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Attribution
This SOP was authored by Organthis based on the published method in Miller et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.
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