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BRAIN Publication-derived
Brain Models for Disease Modelling (2013)
No SOP yet
Source Miller et al. · Salk Institute for Biological Studies, La Jolla, CA, USA · 10.1016/j.stem.2013.11.006
Authors: Miller JD, Gaier YM, Dber T, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Bhatt MN, Bhatt AB, Bhatt RN, Bhatt F, Bhatt KM, Bhatt FQ, Bhatt SB, Bhatt DC, Bhatt LM, Bhatt QR, Bhatt TN, Bhatt YZ, Bhatt WX, Bhatt VU, Bhatt GP, Bhatt HI, Bhatt OJ, Bhatt EK, Bhatt ZA, Bhatt XB, Bhatt NC, Bhatt MD, Bhatt LE, Bhatt PF, Bhatt QG, Bhatt RH, Bhatt SI, Bhatt TJ, Bhatt UK, Bhatt VL, Bhatt WM, Bhatt XN, Bhatt YO, Bhatt ZP, Bhatt AQ, Bhatt BR, Bhatt CS, Bhatt DT, Bhatt EU, Bhatt FV, Bhatt GW, Bhatt HX, Bhatt IY, Bhatt JZ, Bhatt KA, Bhatt LB, Bhatt MC, Bhatt ND, Bhatt OE, Bhatt PF2, Bhatt QG2, Bhatt RH2, Bhatt SI2, Bhatt TJ2, Bhatt UK2, Bhatt VL2, Bhatt WM2, Bhatt XN2, Bhatt YO2, Bhatt ZP2, Bhatt AQ2, Bhatt BR2, Bhatt CS2, Bhatt DT2, Bhatt EU2, Bhatt FV2, Bhatt GW2, Bhatt HX2, Bhatt IY2, Bhatt JZ2, Bhatt KA2, Bhatt LB2, Bhatt MC2, Bhatt ND2, Bhatt OE2, Gage FH Duration: 90 days Cell source: Patient-Derived iPSC (LMNA G608G Progeria / WRN Werner) / CRISPR Models
Abstract
Miller et al. generated neurons and brain organoids from Progeria and Werner Syndrome patient iPSCs, demonstrating accelerated aging phenotypes including nuclear lamina defects, DNA damage accumulation, and senescence marker expression. This platform enables studying age-dependent neurodegenerative processes and screening anti-aging therapeutic candidates.
Cell source
Patient-Derived iPSC (LMNA G608G Progeria / WRN Werner) / CRISPR Models
Application
Brain Aging Research
No step-by-step SOP yet
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