BRAIN Publication-derived

Astrocyte-Oligodendrocyte Organoid

Source Madhavan et al. · Case Western Reserve University, Cleveland, OH, USA · 10.1038/s41592-018-0081-4

👤 Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Tesar PJ ⏱ 72000 min 🧫 Human iPSC

Abstract

Madhavan et al. developed brain organoids containing neurons, astrocytes, and oligodendrocytes that form compact myelin sheaths around axons, demonstrated by transmission electron microscopy. The organoids undergo demyelination upon lysolecithin challenge and subsequent remyelination, enabling screening of remyelination-promoting therapeutics for Multiple Sclerosis.

Cell source

Human iPSC

Application

Multiple Sclerosis Drug Screening

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Madhavan et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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