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BRAIN Publication-derived
Brain Organoids for Drug Screening with Astrocytes
No SOP yet
Source Madhavan et al. · Case Western Reserve University, Cleveland, OH, USA · 10.1038/s41592-018-0081-4
Authors: Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Bhatt SM, Bhatt AH, Bhatt RM, Bhatt KJ, Bhatt NP, Bhatt RS, Bhatt AM, Bhatt JE, Tesar PJ Duration: 150 days Cell source: Human iPSC
Abstract
Madhavan et al. developed brain organoids containing neurons, astrocytes, and oligodendrocytes that form compact myelin sheaths around axons, demonstrated by transmission electron microscopy. The organoids undergo demyelination upon lysolecithin challenge and subsequent remyelination, enabling screening of remyelination-promoting therapeutics for Multiple Sclerosis.
Cell source
Human iPSC
Application
Multiple Sclerosis Drug Screening
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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