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BRAIN Publication-derived
Spinal Cord Organoids for Drug Screening
No SOP yet
Source Sances et al. · Cedars-Sinai Medical Center, Los Angeles, CA, USA · 10.1016/j.stemcr.2018.01.024
Authors: Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, Workman M, Bhatt SM, Svendsen CN Duration: 50 days Cell source: Patient-Derived iPSC (SMA Type I)
Abstract
Sances et al. established SMA patient motor neuron organoids demonstrating SMN restoration and motor neuron rescue upon Nusinersen (ASO) and Risdiplam (small molecule) treatment.
Cell source
Patient-Derived iPSC (SMA Type I)
Application
SMA Disease Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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