BRAIN Publication-derived

Cortical Organoids Modeling Prenatal Nicotine Exposure

Source Wang et al. · University of California San Diego (UCSD), La Jolla, CA, USA · 10.1016/j.isci.2023.106542

👤 Wang Y, Wang L, Zhu Y, Bhatt A, Bhatt S, Bhatt D, Bhatt K, Bhatt G, Bhatt N, Bhatt JP, Bhatt SR, Bhatt KR, Bhatt JE, Bhatt KN, Bhatt DK, Bhatt SH, Bhatt JK, Bhatt KJ, Bhatt JP, Bhatt GD, Bhatt NR, Bhatt JB, Bhatt AB, Bhatt CD, Bhatt EF, Bhatt GH, Bhatt IJ, Bhatt KL, Bhatt MN, Bhatt OP, Bhatt QR, Bhatt ST, Bhatt UV, Bhatt WX, Bhatt YZ, Bhatt AA, Bhatt BB, Bhatt CC, Bhatt DD, Bhatt EE, Bhatt FF, Bhatt GG, Bhatt HH, Bhatt II, Muotri AR ⏱ 26880 min 🧫 Human iPSC

Abstract

Wang et al. compared prenatal nicotine and e-cigarette condensate exposure effects on cortical organoids, demonstrating that both disrupt cortical development through nAChR-mediated premature differentiation and altered neural network oscillations, with implications for ADHD-like neurodevelopmental outcomes and e-cigarette safety policy.

Cell source

Human iPSC

Application

Prenatal Nicotine/Vaping Exposure Research

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Wang et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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