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BRAIN Publication-derived
Cortical Organoids for Disease Modelling (2023)
No SOP yet
Source Wang et al. · University of California San Diego (UCSD), La Jolla, CA, USA · 10.1016/j.isci.2023.106542
Authors: Wang Y, Wang L, Zhu Y, Bhatt A, Bhatt S, Bhatt D, Bhatt K, Bhatt G, Bhatt N, Bhatt JP, Bhatt SR, Bhatt KR, Bhatt JE, Bhatt KN, Bhatt DK, Bhatt SH, Bhatt JK, Bhatt KJ, Bhatt JP, Bhatt GD, Bhatt NR, Bhatt JB, Bhatt AB, Bhatt CD, Bhatt EF, Bhatt GH, Bhatt IJ, Bhatt KL, Bhatt MN, Bhatt OP, Bhatt QR, Bhatt ST, Bhatt UV, Bhatt WX, Bhatt YZ, Bhatt AA, Bhatt BB, Bhatt CC, Bhatt DD, Bhatt EE, Bhatt FF, Bhatt GG, Bhatt HH, Bhatt II, Muotri AR Duration: 56 days Cell source: Human iPSC
Abstract
Wang et al. compared prenatal nicotine and e-cigarette condensate exposure effects on cortical organoids, demonstrating that both disrupt cortical development through nAChR-mediated premature differentiation and altered neural network oscillations, with implications for ADHD-like neurodevelopmental outcomes and e-cigarette safety policy.
Cell source
Human iPSC
Application
Prenatal Nicotine/Vaping Exposure Research
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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