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BRAIN Publication-derived
Brain Organ-on-Chip Models for Drug Screening
No SOP yet
Source Vatine et al. · Cedars-Sinai Medical Center, Los Angeles, CA, USA / Ben-Gurion University, Israel
Authors: Vatine GD, Barrile R, Workman MJ, Sances S, Barber BK, Bhatt JE, Bhatt DK, Bhatt SH, Bhatt JK, Bhatt KJ, Bhatt JP, Bhatt GD, Svendsen CN Duration: 30 days Cell source: Human iPSC
Abstract
Vatine et al. developed an iPSC-derived BBB-on-chip achieving physiological TEER values and functional efflux pump activity, enabling CNS drug permeability screening and modeling patient-specific BBB dysfunction in Huntington's disease.
Cell source
Human iPSC
Application
CNS Drug Permeability Screening
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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