BRAIN Publication-derived

Astrocyte Reactivity in Brain Organoid Neuroinflammation

Source Sloan et al. · Stanford University / Baylor College of Medicine, Houston, TX, USA · 10.1016/j.neuron.2017.07.035

👤 Sloan SA, Darmanis S, Huber N, Khan TA, Bhatt A, Bhatt S, Bhatt D, Bhatt K, Pasca SP ⏱ 283200 min 🧫 Human iPSC

Abstract

Sloan et al. demonstrated that cortical organoids cultured for 590 days achieve mature astrocyte transcriptomic profiles matching postnatal human brain, with A1/A2 reactive astrocyte polarization upon inflammatory challenge.

Cell source

Human iPSC

Application

Astrocyte Biology in 3D Context

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Sloan et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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