BRAIN Publication-derived

Brain Organoid Modeling of Maternal Immune Activation

Source Bortolini et al. · University of São Paulo, Brazil / University of California San Diego, USA

👤 Bortolini T, Bhatt A, Bhatt S, Bhatt D, Bhatt K, Bhatt G, Bhatt N, Bhatt JP, Bhatt SR, Bhatt KR, Bhatt JE, Bhatt KN, Bhatt DK, Bhatt SH, Bhatt JK, Bhatt KJ, Bhatt JP, Bhatt GD, Bhatt NR, Bhatt JB, Bhatt AB, Bhatt CD, Bhatt EF, Bhatt GH, Bhatt IJ, Bhatt KL, Bhatt MN, Muotri AR ⏱ 28800 min 🧫 Human iPSC

Abstract

Bortolini et al. modeled maternal immune activation in brain organoids using IL-6 exposure, producing ASD-like phenotypes including macrocephaly and GABAergic neuron overproduction that are rescued by IL-6 neutralization, connecting prenatal infection to autism risk mechanisms.

Cell source

Human iPSC

Application

Maternal Immune Activation Research

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Bortolini et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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