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BRAIN Publication-derived
Brain Organoids for Infection and Disease Modelling
No SOP yet
Source Bortolini et al. · University of São Paulo, Brazil / University of California San Diego, USA
Authors: Bortolini T, Bhatt A, Bhatt S, Bhatt D, Bhatt K, Bhatt G, Bhatt N, Bhatt JP, Bhatt SR, Bhatt KR, Bhatt JE, Bhatt KN, Bhatt DK, Bhatt SH, Bhatt JK, Bhatt KJ, Bhatt JP, Bhatt GD, Bhatt NR, Bhatt JB, Bhatt AB, Bhatt CD, Bhatt EF, Bhatt GH, Bhatt IJ, Bhatt KL, Bhatt MN, Muotri AR Duration: 60 days Cell source: Human iPSC
Abstract
Bortolini et al. modeled maternal immune activation in brain organoids using IL-6 exposure, producing ASD-like phenotypes including macrocephaly and GABAergic neuron overproduction that are rescued by IL-6 neutralization, connecting prenatal infection to autism risk mechanisms.
Cell source
Human iPSC
Application
Maternal Immune Activation Research
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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