CARDIAC Publication-derived

Directed Differentiation of Human ESCs to Cardiomyocytes

Source Laflamme et al. · Department of Pathology, University of Washington, Seattle, USA

👤 Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, Reinecke H, Xu C, Hassanipour M, Police S, O'Sullivan C, Collins L, Chen Y, Minami E, Gill EA, Ueno S, Yuan C, Gold J, Bhatt S, Murry CE ⏱ 9600 min 🧫 ESC-Derived (Human Embryonic Stem Cells)

Abstract

Laflamme et al. established one of the earliest efficient protocols for directed differentiation of human ESCs to cardiomyocytes using sequential Activin A and BMP4 treatment. The study demonstrated functional engraftment in a rat myocardial infarction model, providing foundational evidence for cardiac cell therapy.

Cell source

ESC-Derived (Human Embryonic Stem Cells)

Application

Cardiac Regeneration

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Laflamme et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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