INTESTINAL Publication-derived

Heart-Forming Organoids from Human Pluripotent Stem Cells

Source Drakhlis et al. · Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School, Hannover, Germany · 10.1038/s41587-021-00815-9

👤 Drakhlis L, Biswas S, Beckmann CM, Rode I, Szarber J, Kuber A, Li Y, Griesbeck A, Farr CM, Karber L, Hauber V, Nogueira A, Wollert KC, Gruh I, Kempf H, Zweigerdt R ⏱ 8640 min 🧫 iPSC-Derived (Human iPSCs/ESCs)

Abstract

Drakhlis et al. created heart-forming organoids that recapitulate the spatial organization of early cardiac development including myocardium, foregut endoderm, and septum transversum-like mesenchyme. NKX2-5 knockout organoids modeled congenital heart defects, demonstrating the platform's utility for developmental biology and disease modeling in a scalable format.

Cell source

iPSC-Derived (Human iPSCs/ESCs)

Application

Heart-Foregut Development

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Drakhlis et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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