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INTESTINAL Publication-derived
Intestinal Organoids for Developmental Studies
No SOP yet
Source Drakhlis et al. · Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School, Hannover, Germany · 10.1038/s41587-021-00815-9
Authors: Drakhlis L, Biswas S, Beckmann CM, Rode I, Szarber J, Kuber A, Li Y, Griesbeck A, Farr CM, Karber L, Hauber V, Nogueira A, Wollert KC, Gruh I, Kempf H, Zweigerdt R Duration: 18 days Cell source: iPSC-Derived (Human iPSCs/ESCs)
Abstract
Drakhlis et al. created heart-forming organoids that recapitulate the spatial organization of early cardiac development including myocardium, foregut endoderm, and septum transversum-like mesenchyme. NKX2-5 knockout organoids modeled congenital heart defects, demonstrating the platform's utility for developmental biology and disease modeling in a scalable format.
Cell source
iPSC-Derived (Human iPSCs/ESCs)
Application
Heart-Foregut Development
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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