CARDIAC Publication-derived

Atrial-Specific Cardiomyocyte Differentiation via Retinoic Acid

Source Devalla et al. · Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, Netherlands · 10.15252/emmm.201404757

👤 Devalla HD, Schwach V, Ford JW, Milnes JT, El-Haou S, Jackson C, Schmitt K, Bezzina CR, Passier R, Mummery CL ⏱ 9600 min 🧫 iPSC-Derived (Human iPSCs/ESCs)

Abstract

Devalla et al. established an efficient protocol for generating atrial-specific cardiomyocytes from human pluripotent stem cells using retinoic acid during the cardiac differentiation window. Atrial CMs display characteristic action potential morphology and respond to atrial-selective drugs like vernakalant, creating a platform for atrial fibrillation research and drug screening.

Cell source

iPSC-Derived (Human iPSCs/ESCs)

Application

Atrial Fibrillation Drug Testing

Full SOP

🔬

Create a free account to access this protocol

Join OrganMatch to unlock step-by-step procedures, reagent concentrations, QC checklists, and downloadable batch record templates.

Create free account

Already registered? Log in

Attribution

This SOP was authored by Organthis based on the published method in Devalla et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

This wording is awaiting legal review.

Something wrong with this entry? Report an issue with this protocol

Need a commercial licence?

Use this protocol in your therapeutic or diagnostic pipeline.

Request Commercial Licence