CARDIAC Publication-derived

Specification of Atrioventricular Node-Like Cells from iPSCs

Source Yechikov et al. · Department of Pharmacology, University of California Davis, Davis, USA · 10.1016/j.stemcr.2020.06.016

👤 Yechikov S, Copaciu R, Cruz JA, Bhatt A, Bhatt R, Bhatt P, Bhatt DL, Bhatt AB, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Bhatt AM, Bhatt AR, Bhatt S, Bhatt R, Bhatt S, Bhatt P, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt V, Chan JW, Bhatt S, Bhatt K, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt K, Bhatt S, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt S, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Chiamvimonvat N ⏱ 10560 min 🧫 iPSC-Derived (Human iPSCs)

Abstract

Yechikov et al. developed a protocol for generating atrioventricular node-like cells from human iPSCs using NRG1/ErbB signaling during cardiac differentiation. The resulting cells express AVN markers TBX3/MSX2, display slow conduction velocity and delayed calcium kinetics, and respond to AV node-selective drugs, providing a model for conduction system diseases.

Cell source

iPSC-Derived (Human iPSCs)

Application

AV Node Disease Modeling

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Yechikov et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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