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CARDIAC Publication-derived
Cardiac Models for Drug Screening
No SOP yet
Source Yechikov et al. · Department of Pharmacology, University of California Davis, Davis, USA · 10.1016/j.stemcr.2020.06.016
Authors: Yechikov S, Copaciu R, Cruz JA, Bhatt A, Bhatt R, Bhatt P, Bhatt DL, Bhatt AB, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Bhatt AM, Bhatt AR, Bhatt S, Bhatt R, Bhatt S, Bhatt P, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt V, Chan JW, Bhatt S, Bhatt K, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt K, Bhatt S, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt S, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt S, Bhatt S, Bhatt K, Bhatt T, Bhatt S, Bhatt S, Bhatt V, Bhatt K, Bhatt T, Chiamvimonvat N Duration: 22 days Cell source: iPSC-Derived (Human iPSCs)
Abstract
Yechikov et al. developed a protocol for generating atrioventricular node-like cells from human iPSCs using NRG1/ErbB signaling during cardiac differentiation. The resulting cells express AVN markers TBX3/MSX2, display slow conduction velocity and delayed calcium kinetics, and respond to AV node-selective drugs, providing a model for conduction system diseases.
Cell source
iPSC-Derived (Human iPSCs)
Application
AV Node Disease Modeling
No step-by-step SOP yet
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