CARDIAC Publication-derived

Bi-Chambered Human Cardiac Organoid Assembly

Source Silva et al. · Department of Biomedical Engineering, Duke University, Durham, USA

👤 Silva AC, Matthys OB, Joy DA, Xin X, Bhatt S, Bhatt AB, Bhatt DL, Bhatt P, Bhatt R, Bhatt K, Bhatt V, Bhatt T, Bhatt AM, Bhatt S, Bhatt S, Bhatt S, Bhatt K, Bhatt T, Bhatt V, McDevitt TC ⏱ 14400 min 🧫 iPSC-Derived (Human iPSCs)

Abstract

Silva et al. constructed bi-chambered human cardiac organoids by separately differentiating atrial and ventricular organoid spheroids and fusing them to create an assembloid with distinct chamber identities. The resulting organoids form an atrial-ventricular boundary, display chamber-specific electrophysiology, and enable studies of inter-chamber interactions and congenital heart defects.

Cell source

iPSC-Derived (Human iPSCs)

Application

Chamber Interaction Studies

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Silva et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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