CARDIAC Publication-derived

Tubules

Source Mills et al. · QIMR Berghofer Medical Research Institute, Brisbane, Australia · 10.1073/pnas.1702914114

👤 Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodge MP, Ferguson C, Drowley L, Plober AT, Needham EJ, Li QY, Porrello ER, Delbridge LM, Thomas A, Gregorevic P, Parton RG, Li LI, Hawkins SJ, Hudson JE ⏱ 13440 min 🧫 iPSC-Derived (Human iPSCs)

Abstract

Mills et al. developed human cardiac organoids (hCOs) that achieve structural and metabolic maturation through a fatty acid metabolic switching protocol. The resulting compact ventricular muscle organoids form T-tubules, exhibit mature calcium handling, and show positive force-frequency relationships, providing a more physiologically relevant platform for drug screening and disease modeling.

Cell source

iPSC-Derived (Human iPSCs)

Application

Cardiac Maturation Studies

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Mills et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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