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CARDIAC Publication-derived
Cardiac Spheroids for Drug Screening
No SOP yet
Source Giacomelli et al. · Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands · 10.1016/j.stem.2020.05.004
Authors: Giacomelli E, Meraviglia V, Campostrini G, Cochrane A, Cao X, van Helden RWJ, Krotenberg Garcia A, Mirber M, Kutber T, Davis RP, Bellin M, Mummery CL Duration: 20 days Cell source: iPSC-Derived (Human iPSCs)
Abstract
Giacomelli et al. developed tri-cell cardiac microtissues by self-assembly of iPSC-derived cardiomyocytes, endothelial cells, and cardiac fibroblasts. The multi-cell composition enhances cardiomyocyte maturation and drug sensitivity compared to monoculture, providing a scalable platform for high-throughput cardiotoxicity screening in standard multi-well formats.
Cell source
iPSC-Derived (Human iPSCs)
Application
High-Throughput Cardiotoxicity Screening
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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