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CARDIAC Publication-derived
Cardiac Assembloids for Developmental Studies
No SOP yet
Source Lee et al. · Department of Cell Biology, Duke University Medical Center, Durham, USA · 10.1016/j.stemcr.2022.07.002
Authors: Lee SG, Kim YJ, Son MY, Oh MS, Kim J, Ryu B, Kang KR, Baek J, Chung G, Bhatt S, Bhatt AB, Bhatt P, Woo DH, Kim CJ Duration: 35 days Cell source: iPSC-Derived (Human iPSCs)
Abstract
Lee et al. generated the most complex human heart organoid to date, featuring four distinct chamber-like regions corresponding to atrial, ventricular, inflow, and outflow tract identities. Multi-step growth factor patterning recapitulates early heart development, and spatial transcriptomics confirms region-specific gene expression, enabling studies of complex congenital heart diseases and whole-heart pharmacology.
Cell source
iPSC-Derived (Human iPSCs)
Application
Whole-Heart Development Studies
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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