Four-Chamber Human Heart Organoid
Source Lee et al. · Department of Cell Biology, Duke University Medical Center, Durham, USA · 10.1016/j.stemcr.2022.07.002
Abstract
Lee et al. generated the most complex human heart organoid to date, featuring four distinct chamber-like regions corresponding to atrial, ventricular, inflow, and outflow tract identities. Multi-step growth factor patterning recapitulates early heart development, and spatial transcriptomics confirms region-specific gene expression, enabling studies of complex congenital heart diseases and whole-heart pharmacology.
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Attribution
This SOP was authored by Organthis based on the published method in Lee et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.
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