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CARDIAC Publication-derived
Cardiomyopathy Cardiac 2D Cell Cultures
No SOP yet
Source Lan et al. · Stanford Cardiovascular Institute, Stanford University, Stanford, USA · 10.1016/j.stem.2012.10.010
Authors: Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Bhatt DL, Wu JC Duration: 30 days Cell source: iPSC-Derived (Patient-Specific iPSCs — HCM)
Abstract
Lan et al. generated patient-specific iPSC-cardiomyocytes carrying the HCM-causing MYH7 R403Q mutation, demonstrating cellular hypertrophy, sarcomeric disarray, and calcium handling abnormalities. This disease-in-a-dish model validated therapeutic candidates including myosin inhibitors and established the paradigm for iPSC-based cardiomyopathy modeling.
Cell source
iPSC-Derived (Patient-Specific iPSCs — HCM)
Application
HCM Drug Discovery
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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