CARDIAC Publication-derived

IPSC-CM Model of Hypertrophic Cardiomyopathy (MYH7 R403Q)

Source Lan et al. · Stanford Cardiovascular Institute, Stanford University, Stanford, USA · 10.1016/j.stem.2012.10.010

👤 Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Bhatt DL, Wu JC ⏱ 14400 min 🧫 iPSC-Derived (Patient-Specific iPSCs — HCM)

Abstract

Lan et al. generated patient-specific iPSC-cardiomyocytes carrying the HCM-causing MYH7 R403Q mutation, demonstrating cellular hypertrophy, sarcomeric disarray, and calcium handling abnormalities. This disease-in-a-dish model validated therapeutic candidates including myosin inhibitors and established the paradigm for iPSC-based cardiomyopathy modeling.

Cell source

iPSC-Derived (Patient-Specific iPSCs — HCM)

Application

HCM Drug Discovery

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Lan et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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