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CARDIAC Publication-derived
Cardiac Models for Drug Screening (2010)
No SOP yet
Source Moretti et al. · Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Authors: Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flugel L, Dorn T, Goedel A, Hohnke C, Hofmann F, Seyfarth M, Seidman CE, Seidman JG, Laugwitz KL Duration: 28 days Cell source: iPSC-Derived (Patient-Specific iPSCs — LQTS1)
Abstract
Moretti et al. generated the first clinically published iPSC-cardiomyocyte model of Long QT Syndrome type 1, using patient-specific iPSCs carrying the KCNQ1 R190Q mutation. LQTS1 iPSC-CMs showed reduced IKs current, prolonged action potential duration, and β-adrenergically provoked early afterdepolarizations, recapitulating the clinical phenotype and enabling drug screening.
Cell source
iPSC-Derived (Patient-Specific iPSCs — LQTS1)
Application
LQTS Drug Screening
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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