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CARDIAC Publication-derived
Cardiac Models for Drug Screening (2011)
No SOP yet
Source Itzhaki et al. · Sohnis Research Laboratory for Cardiac Electrophysiology, Technion – Israel Institute of Technology, Haifa, Israel
Authors: Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, Feldman O, Gepstein A, Arbel G, Hammerman H, Boulos M, Gepstein L Duration: 28 days Cell source: iPSC-Derived (Patient-Specific iPSCs — LQTS2)
Abstract
Itzhaki et al. generated patient-specific iPSC-cardiomyocytes carrying the hERG A614V mutation causing LQTS2. These cells displayed prolonged action potentials, reduced IKr current, and early afterdepolarizations. Pharmacological rescue with calcium channel blockers and K-ATP openers validated the model for therapeutic drug screening.
Cell source
iPSC-Derived (Patient-Specific iPSCs — LQTS2)
Application
LQTS2 Drug Screening
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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