CARDIAC Publication-derived

CM [cmpwi4]

Source Yazawa et al. · Department of Molecular Pharmacology, Columbia University, New York, USA · 10.1038/nature09855

👤 Yazawa M, Hsueh B, Jia X, Pasca AM, Bernstein JA, Bhatt S, Hallmayer J, Bhatt DL, Dolmetsch RE ⏱ 13440 min 🧫 iPSC-Derived (Patient-Specific iPSCs — Timothy Syndrome)

Abstract

Yazawa et al. generated iPSC-CMs from Timothy syndrome patients carrying the CACNA1C G406R mutation, demonstrating delayed L-type calcium channel inactivation, prolonged action potentials, and irregular calcium cycling. Roscovitine was identified as a therapeutic candidate that rescues the electrophysiological phenotype by restoring calcium channel kinetics.

Cell source

iPSC-Derived (Patient-Specific iPSCs — Timothy Syndrome)

Application

L-Type Calcium Channel Studies

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Yazawa et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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