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CARDIAC Publication-derived
Cardiac Models for Disease Modelling
No SOP yet
Source Yazawa et al. · Department of Molecular Pharmacology, Columbia University, New York, USA · 10.1038/nature09855
Authors: Yazawa M, Hsueh B, Jia X, Pasca AM, Bernstein JA, Bhatt S, Hallmayer J, Bhatt DL, Dolmetsch RE Duration: 28 days Cell source: iPSC-Derived (Patient-Specific iPSCs — Timothy Syndrome)
Abstract
Yazawa et al. generated iPSC-CMs from Timothy syndrome patients carrying the CACNA1C G406R mutation, demonstrating delayed L-type calcium channel inactivation, prolonged action potentials, and irregular calcium cycling. Roscovitine was identified as a therapeutic candidate that rescues the electrophysiological phenotype by restoring calcium channel kinetics.
Cell source
iPSC-Derived (Patient-Specific iPSCs — Timothy Syndrome)
Application
L-Type Calcium Channel Studies
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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