Back to browse
CARDIAC Publication-derived
Cardiomyopathy Cardiac Models
No SOP yet
Source Wang et al. · Department of Biomedical Engineering, Wyss Institute, Harvard University, Boston, USA · 10.1038/nm.3545
Authors: Wang G, McCain ML, Yang L, He A, Bhatt DL, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kuber W, Church GM, Bhatt S, Parker KK, Bhatt AB, Pu WT Duration: 35 days Cell source: iPSC-Derived (Patient-Specific iPSCs — Barth Syndrome)
Abstract
Wang et al. combined patient iPSC-CMs with muscular thin film technology to model Barth syndrome, revealing that TAZ mutations cause cardiolipin remodeling defects, mitochondrial fragmentation, and impaired contractility. TAZ mRNA delivery rescued the phenotype, providing proof-of-concept for gene therapy approaches to this mitochondrial cardiomyopathy.
Cell source
iPSC-Derived (Patient-Specific iPSCs — Barth Syndrome)
Application
Mitochondrial Cardiomyopathy
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
Something wrong with this entry? Report an issue with this protocol