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CARDIAC Publication-derived
Cardiac Models for Toxicity Testing
No SOP yet
Source Burridge et al. · Stanford Cardiovascular Institute, Stanford University, Stanford, USA · 10.1038/nm.4087
Authors: Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holber A, Diecke S, Wu JC Duration: 21 days Cell source: iPSC-Derived (Patient-Specific iPSCs — Breast Cancer Patients)
Abstract
Burridge et al. demonstrated that iPSC-CMs from breast cancer patients who developed clinical doxorubicin cardiotoxicity were more sensitive to doxorubicin in vitro than those from resilient patients. This personalized approach enables individual risk stratification and identified genetic variants associated with anthracycline susceptibility.
Cell source
iPSC-Derived (Patient-Specific iPSCs — Breast Cancer Patients)
Application
Anthracycline Cardiotoxicity Prediction
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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