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CARDIAC Publication-derived
Cardiac Models for Drug Screening and Toxicity Testing
No SOP yet
Source Sharma et al. · Stanford Cardiovascular Institute, Stanford University, Stanford, USA · 10.1126/scitranslmed.aaf2584
Authors: Sharma A, Burridge PW, McKeithan WL, Serber F, Shi X, Holber A, Yeber P, Bhatt DL, Wu JC Duration: 14 days Cell source: iPSC-Derived (Human iPSCs — Multiple Lines)
Abstract
Sharma et al. screened 21 FDA-approved tyrosine kinase inhibitors against iPSC-CMs, developing a cardiac safety index that correlates with clinical cardiotoxicity reports from the FDA Adverse Event Reporting System. The study identified VEGFR/PDGFR pathway inhibition as the primary mechanism and established a scalable preclinical screening paradigm for oncology cardiotoxicity.
Cell source
iPSC-Derived (Human iPSCs — Multiple Lines)
Application
TKI Safety Profiling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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