CARDIAC Publication-derived

Biowire Platform for Cardiac Tissue Maturation

Source Nunes et al. · Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada · 10.1038/nmeth.2524

👤 Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Masse S, Gagber M, Bhatt DL, Hber K, Bhatt S, Backx PH, Bhatt AB, Bhatt P, Bhatt K, Radisic M ⏱ 10080 min 🧫 iPSC-Derived (Human iPSCs/ESCs)

Abstract

Nunes et al. developed the Biowire platform where iPSC-derived cardiac cells are seeded in collagen around a suture wire template and matured through progressive electrical frequency stimulation. The resulting tissues achieve adult-like conduction velocity, sarcomere organization, and force generation, establishing a mature cardiac model for drug testing.

Cell source

iPSC-Derived (Human iPSCs/ESCs)

Application

Cardiac Tissue Maturation

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Nunes et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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