Back to browse
CARDIAC Publication-derived
Cardiac Organ-on-Chip Models for Developmental Studies
No SOP yet
Source Nunes et al. · Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada · 10.1038/nmeth.2524
Authors: Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Masse S, Gagber M, Bhatt DL, Hber K, Bhatt S, Backx PH, Bhatt AB, Bhatt P, Bhatt K, Radisic M Duration: 21 days Cell source: iPSC-Derived (Human iPSCs/ESCs)
Abstract
Nunes et al. developed the Biowire platform where iPSC-derived cardiac cells are seeded in collagen around a suture wire template and matured through progressive electrical frequency stimulation. The resulting tissues achieve adult-like conduction velocity, sarcomere organization, and force generation, establishing a mature cardiac model for drug testing.
Cell source
iPSC-Derived (Human iPSCs/ESCs)
Application
Cardiac Tissue Maturation
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
Something wrong with this entry? Report an issue with this protocol