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CARDIAC Publication-derived
Cardiac Organ-on-Chip Models for Drug Screening
No SOP yet
Source Mathur et al. · Department of Bioengineering, University of California Berkeley, Berkeley, USA · 10.1038/srep08883
Authors: Mathur A, Lber P, Seo J, Terber C, Dahey TH, Bhatt S, Bhatt DL, Bhatt AB, Bhatt P, Bhatt K, Healy KE Duration: 14 days Cell source: iPSC-Derived (Human iPSC-CMs)
Abstract
Mathur et al. developed a microfluidic heart-on-chip with continuous perfusion of iPSC-CMs, demonstrating that flow-based drug exposure shifts IC50 values closer to clinical plasma concentrations compared to static culture. The platform provides pharmacokinetically relevant drug testing in a format compatible with multi-organ chip integration.
Cell source
iPSC-Derived (Human iPSC-CMs)
Application
Microfluidic Cardiac Drug Testing
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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