Heart-on-Chip Microphysiological
Source Mathur et al. · Department of Bioengineering, University of California Berkeley, Berkeley, USA · 10.1038/srep08883
Abstract
Mathur et al. developed a microfluidic heart-on-chip with continuous perfusion of iPSC-CMs, demonstrating that flow-based drug exposure shifts IC50 values closer to clinical plasma concentrations compared to static culture. The platform provides pharmacokinetically relevant drug testing in a format compatible with multi-organ chip integration.
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Attribution
This SOP was authored by Organthis based on the published method in Mathur et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.
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