LIVER Publication-derived

On-Chips with Cardiac, Liver, and Lung Modules

Source Herland et al. · Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA · 10.1038/s41551-019-0497-x

👤 Herland A, Maoz BM, Das D, Stucki JD, FitzGerald EA, Bhatt S, Bhatt DL, Novak R, Bhatt AB, Bhatt P, Bhatt K, Ingber DE ⏱ 13440 min 🧫 iPSC-Derived (Human iPSC-CMs + Primary Cells)

Abstract

Herland et al. developed a 10-organ linked human body-on-chip system where the cardiac module receives drugs metabolized by liver, kidney, and other organ chips. The fluidically linked system enables physiologically based pharmacokinetic predictions of drug distribution and organ-specific toxicity, representing the most comprehensive body-on-chip platform validated for drug development.

Cell source

iPSC-Derived (Human iPSC-CMs + Primary Cells)

Application

Multi-Organ PK/PD Modeling

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Herland et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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