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LIVER Publication-derived
Liver Organ-on-Chip Models for Toxicity Testing
No SOP yet
Source Herland et al. · Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA · 10.1038/s41551-019-0497-x
Authors: Herland A, Maoz BM, Das D, Stucki JD, FitzGerald EA, Bhatt S, Bhatt DL, Novak R, Bhatt AB, Bhatt P, Bhatt K, Ingber DE Duration: 28 days Cell source: iPSC-Derived (Human iPSC-CMs + Primary Cells)
Abstract
Herland et al. developed a 10-organ linked human body-on-chip system where the cardiac module receives drugs metabolized by liver, kidney, and other organ chips. The fluidically linked system enables physiologically based pharmacokinetic predictions of drug distribution and organ-specific toxicity, representing the most comprehensive body-on-chip platform validated for drug development.
Cell source
iPSC-Derived (Human iPSC-CMs + Primary Cells)
Application
Multi-Organ PK/PD Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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