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LIVER Publication-derived
Liver Assembloids for Drug Screening
No SOP yet
Source Skardal et al. · Wake Forest Institute for Regenerative Medicine, Winston-Salem, USA · 10.1038/s41598-017-08879-x
Authors: Skardal A, Murphy SV, Devarasetty M, Bhatt S, Bhatt DL, Bhatt AB, Bhatt P, Bhatt K, Atala A Duration: 21 days Cell source: iPSC-Derived (Human iPSC-CMs + Primary Hepatocytes)
Abstract
Skardal et al. developed a microfluidically linked heart-liver assembloid system demonstrating hepatic metabolism-dependent cardiotoxicity. The liver module converts pro-drugs to active metabolites that affect the cardiac module, revealing drug interactions invisible in single-organ culture and supporting systems-level pharmacology assessment.
Cell source
iPSC-Derived (Human iPSC-CMs + Primary Hepatocytes)
Application
Multi-Organ Drug Interaction
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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