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BRAIN Publication-derived
Brain Assembloids (2020)
No SOP yet
Source Xiang et al. · Department of Biomedical Engineering, Duke University, Durham, USA · 10.1016/j.stem.2020.06.004
Authors: Xiang Y, Tanaka Y, Patterson B, Bhatt S, Bhatt DL, Bhatt AB, Bhatt P, Bhatt K, Park IH Duration: 35 days Cell source: iPSC-Derived (Human iPSC-CMs + iPSC-Sympathetic Neurons)
Abstract
Xiang et al. generated cardiac-sympathetic neuron assembloids where iPSC-derived sympathetic neurons form functional contacts with cardiomyocytes. Sympathetic innervation drives norepinephrine-mediated chronotropy antagonized by β-blockers, creating the first human model of autonomic cardiac regulation for drug testing and innervation studies.
Cell source
iPSC-Derived (Human iPSC-CMs + iPSC-Sympathetic Neurons)
Application
Autonomic Cardiac Regulation
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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