BRAIN Publication-derived

Heart-Brain Assembloid for Autonomic Cardiac Regulation

Source Xiang et al. · Department of Biomedical Engineering, Duke University, Durham, USA · 10.1016/j.stem.2020.06.004

👤 Xiang Y, Tanaka Y, Patterson B, Bhatt S, Bhatt DL, Bhatt AB, Bhatt P, Bhatt K, Park IH ⏱ 16800 min 🧫 iPSC-Derived (Human iPSC-CMs + iPSC-Sympathetic Neurons)

Abstract

Xiang et al. generated cardiac-sympathetic neuron assembloids where iPSC-derived sympathetic neurons form functional contacts with cardiomyocytes. Sympathetic innervation drives norepinephrine-mediated chronotropy antagonized by β-blockers, creating the first human model of autonomic cardiac regulation for drug testing and innervation studies.

Cell source

iPSC-Derived (Human iPSC-CMs + iPSC-Sympathetic Neurons)

Application

Autonomic Cardiac Regulation

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Xiang et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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