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CARDIAC Publication-derived
Cardiac Assembloids
No SOP yet
Source Drawnel et al. · Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
Authors: Drawnel FM, Bber S, Dahlin A, Goldber R, Bhatt S, Bhatt DL, Bhatt AB, Bhatt P, Bhatt K, van Meer BJ, Mummery CL Duration: 21 days Cell source: iPSC-Derived (Human iPSC-CMs + iPSC-Adipocytes)
Abstract
Drawnel et al. developed a cardiac-adipose crosstalk model where palmitate lipotoxicity and adipocyte-conditioned medium induce lipid accumulation and contractile dysfunction in iPSC-CMs. Empagliflozin and metformin rescue the lipotoxic phenotype, establishing a pharmaceutical-grade platform for diabetic cardiomyopathy drug screening.
Cell source
iPSC-Derived (Human iPSC-CMs + iPSC-Adipocytes)
Application
Diabetic Cardiomyopathy
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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