Cardiac-Adipose Assembloid for Metabolic Heart Disease
Source Drawnel et al. · Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
Abstract
Drawnel et al. developed a cardiac-adipose crosstalk model where palmitate lipotoxicity and adipocyte-conditioned medium induce lipid accumulation and contractile dysfunction in iPSC-CMs. Empagliflozin and metformin rescue the lipotoxic phenotype, establishing a pharmaceutical-grade platform for diabetic cardiomyopathy drug screening.
Full SOP
Create a free account to access this protocol
Join OrganMatch to unlock step-by-step procedures, reagent concentrations, QC checklists, and downloadable batch record templates.
Create free accountAlready registered? Log in
Attribution
This SOP was authored by Organthis based on the published method in Drawnel et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.
This wording is awaiting legal review.
Something wrong with this entry? Report an issue with this protocol