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CARDIAC Publication-derived
Cardiac Assembloids for Disease Modelling
No SOP yet
Source Ronaldson-Bouchard et al. · Department of Biomedical Engineering, Columbia University, New York, USA · 10.1038/s41551-022-00882-6
Authors: Ronaldson-Bouchard K, Teles D, Yeager K, Bhatt S, Bhatt DL, Bhatt AB, Bhatt P, Tavakol DN, Zhao Y, Chien A, Vunjak-Novakovic G Duration: 35 days Cell source: iPSC-Derived (Human iPSC-CMs + iPSC-Kidney Organoids)
Abstract
Ronaldson-Bouchard et al. developed a microfluidically linked cardiac-kidney multi-organ system where cisplatin-induced kidney injury triggers secondary cardiac dysfunction through shared circulation. The platform models cardiorenal syndrome, demonstrating inter-organ crosstalk and enabling assessment of drug-induced multi-organ toxicity cascades.
Cell source
iPSC-Derived (Human iPSC-CMs + iPSC-Kidney Organoids)
Application
Cardiorenal Syndrome Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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