CARDIAC Publication-derived

Decellularized Porcine Heart ECM for Human Cardiac Engineering

Source Guyette et al. · Center for Regenerative Medicine, Massachusetts General Hospital, Boston, USA · 10.1161/circresaha.115.306874

👤 Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okumi T, Bhatt S, Bhatt DL, Bhatt AB, Ott HC ⏱ 16800 min 🧫 iPSC-Derived (Human iPSC-CMs on Porcine Decellularized Scaffold)

Abstract

Guyette et al. decellularized 73 human cadaveric and porcine hearts, establishing a clinical-scale scaffold bank. Recellularization with human iPSC-CMs via coronary perfusion achieves regional repopulation and visible contractile function after 14 days, advancing whole-heart tissue engineering toward clinical application.

Cell source

iPSC-Derived (Human iPSC-CMs on Porcine Decellularized Scaffold)

Application

Whole Heart Engineering

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Guyette et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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