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CARDIAC Publication-derived
Cardiac 2D Cell Cultures for Disease Modelling
No SOP yet
Source Kinnear et al. · McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Canada · 10.1002/stem.1325
Authors: Kinnear C, Chang WY, Khattak S, Bhatt S, Bhatt DL, Bhatt AB, Bhatt P, Bhatt K, Bhatt V, Ellis J, Stanford WL Duration: 28 days Cell source: iPSC-Derived (Patient iPSCs — Williams-Beuren Syndrome 7q11.23 Deletion)
Abstract
Kinnear et al. modeled Williams-Beuren syndrome using patient iPSC-derived cardiomyocytes and smooth muscle cells. Elastin haploinsufficiency from 7q11.23 deletion causes smooth muscle hyperproliferation and defective elastin fiber assembly, recapitulating the supravalvular aortic stenosis mechanism and enabling therapeutic target exploration.
Cell source
iPSC-Derived (Patient iPSCs — Williams-Beuren Syndrome 7q11.23 Deletion)
Application
Williams-Beuren Syndrome Modeling
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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