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CARDIAC Publication-derived
Cardiac 2D Cell Cultures for Regenerative Medicine (2014)
No SOP yet
Source Chong et al. · Center for Cardiovascular Biology, University of Washington, Seattle, USA · 10.1038/nature13233
Authors: Chong JJH, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Murry CE Duration: 90 days Cell source: ESC-Derived (Human ESC-CMs — Transplantation-Grade)
Abstract
Chong et al. transplanted 1 billion human ESC-CMs into macaque hearts post-MI, achieving large engraftment with in vivo maturation and electromechanical coupling. The Nature 2014 landmark study demonstrated feasibility but identified transient ventricular arrhythmias as a key safety concern for clinical translation.
Cell source
ESC-Derived (Human ESC-CMs — Transplantation-Grade)
Application
Cardiac Cell Therapy NHP Validation
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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