CARDIAC Publication-derived

IPSC-CM Transplantation in Non-Human Primate MI

Source Chong et al. · Center for Cardiovascular Biology, University of Washington, Seattle, USA · 10.1038/nature13233

👤 Chong JJH, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Murry CE ⏱ 43200 min 🧫 ESC-Derived (Human ESC-CMs — Transplantation-Grade)

Abstract

Chong et al. transplanted 1 billion human ESC-CMs into macaque hearts post-MI, achieving large engraftment with in vivo maturation and electromechanical coupling. The Nature 2014 landmark study demonstrated feasibility but identified transient ventricular arrhythmias as a key safety concern for clinical translation.

Cell source

ESC-Derived (Human ESC-CMs — Transplantation-Grade)

Application

Cardiac Cell Therapy NHP Validation

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Chong et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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