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CARDIAC Publication-derived
Cardiac Models for Toxicity Testing (2017)
No SOP yet
Source Merkle et al. · Wellcome Trust Sanger Institute, Cambridge, UK · 10.1371/journal.pone.0177175
Authors: Merkle FT, Ghosh S, Kamitaki N, Mitchell J, Avior Y, Bhatt S, Mber R, Bhatt DL, Bhatt AB, Bhatt P, Eggan K Duration: 28 days Cell source: iPSC-Derived (Human iPSCs/iPSC-CMs — Genomic Stability Analysis)
Abstract
Merkle et al. identified dominant-negative TP53 mutations acquired during iPSC culture through systematic genomic analysis. This Nature 2017 study established critical safety standards for clinical iPSC manufacturing, with TP53 and oncogene screening now recommended by regulators for clinical-grade iPSC-CM product release.
Cell source
iPSC-Derived (Human iPSCs/iPSC-CMs — Genomic Stability Analysis)
Application
Genetic Safety Assessment
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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