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INTESTINAL Publication-derived
Intestinal Organoids for Developmental Studies (2018)
No SOP yet
Source Takahashi et al. · Tokyo Institute of Technology / Shionogi Pharmaceutical, Yokohama/Osaka, Japan · 10.1016/j.stemcr.2017.11.008
Authors: Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Sato T, Kiyono H Duration: 50 days Cell source: Human iPSC
Abstract
Optimized the iPSC-derived intestinal organoid protocol for pharmaceutical drug absorption and metabolism studies. The refined system produces epithelial cells with functional drug transporters (P-gp) and metabolic enzymes (CYP3A4), providing a human-relevant platform for ADME testing.
Cell source
Human iPSC
Application
Drug Absorption Studies
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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