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INTESTINAL Publication-derived
Inflammatory Bowel Disease Intestinal Organoids
No SOP yet
Source Howell et al. · University of Cambridge, UK · 10.1136/gutjnl-2016-312623
Authors: Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mber TM, Koo BK, Kumar N, Zilbauer M Duration: 21 days Cell source: Primary (Human Intestinal Crypts or iPSC-Derived)
Abstract
Developed a TNF-α-driven intestinal organoid damage model recapitulating key epithelial pathology of IBD including barrier disruption and apoptosis. Anti-TNF biologics rescued damage in a dose-dependent manner, establishing a functional drug screening platform for inflammatory bowel disease therapeutics.
Cell source
Primary (Human Intestinal Crypts or iPSC-Derived)
Application
IBD Drug Screening
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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