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INTESTINAL Publication-derived
Intestinal Organoids for Developmental Studies (2020)
No SOP yet
Source Nanki et al. · Keio University School of Medicine, Tokyo, Japan
Authors: Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K, Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Togasaki K, Kanai T, Sato T Duration: 35 days Cell source: Patient-Derived (UC and Control Colonic Biopsies, Large Cohort)
Abstract
Conducted large-scale organoid phenotyping from UC patients revealing intrinsic stem cell dysfunction including reduced clonogenicity and altered Wnt signaling dependency. Single-cell RNA-seq identified UC-specific stem cell subpopulations with abnormal lineage allocation, establishing stem cell biology as a key axis in UC pathogenesis.
Cell source
Patient-Derived (UC and Control Colonic Biopsies, Large Cohort)
Application
UC Stem Cell Biology
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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