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INTESTINAL Publication-derived
Intestinal Organoids for Regenerative Medicine (2015)
No SOP yet
Source Lindemans et al. · Memorial Sloan Kettering Cancer Center, New York, USA · 10.1038/nature16460
Authors: Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Shroyer NF, Hanash AM Duration: 14 days Cell source: Primary (Human and Mouse Intestinal Crypts)
Abstract
Demonstrated that IL-22 promotes intestinal stem cell recovery via STAT3 signaling in organoid models of radiation and chemotherapy damage. IL-22 treatment expanded Lgr5+ stem cells and accelerated organoid reconstitution, providing mechanistic support for IL-22 as a mucosal regenerative therapy in GVHD and IBD.
Cell source
Primary (Human and Mouse Intestinal Crypts)
Application
Mucosal Regeneration
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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