INTESTINAL Publication-derived

IL-22 Promotes Intestinal Stem Cell Recovery in Organoid Damage

Source Lindemans et al. · Memorial Sloan Kettering Cancer Center, New York, USA · 10.1038/nature16460

👤 Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Shroyer NF, Hanash AM ⏱ 6720 min 🧫 Primary (Human and Mouse Intestinal Crypts)

Abstract

Demonstrated that IL-22 promotes intestinal stem cell recovery via STAT3 signaling in organoid models of radiation and chemotherapy damage. IL-22 treatment expanded Lgr5+ stem cells and accelerated organoid reconstitution, providing mechanistic support for IL-22 as a mucosal regenerative therapy in GVHD and IBD.

Cell source

Primary (Human and Mouse Intestinal Crypts)

Application

Mucosal Regeneration

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Lindemans et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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