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INTESTINAL Publication-derived
Intestinal Organoids (2018, No. 2)
No SOP yet
Source Kasendra et al. · Emulate Inc. and Harvard University, Boston, USA · 10.1038/s41598-018-21201-7
Authors: Kasendra M, Tovaglieri A, Sontheimer-Phelps A, Jalili-Firoozinezhad S, Bein A, Chalkiadaki A, Scholl W, Zhang C, Rickner H, Richmond CA, Li H, Breault DT, Ingber DE Duration: 21 days Cell source: Primary (Human Intestinal Biopsy-Derived Organoid Cells)
Abstract
Developed a primary human intestine-chip by seeding organoid-derived epithelial cells opposite vascular endothelium in the Emulate platform. The chip's transcriptome more closely resembled in vivo duodenum than organoids or Caco-2, with enhanced CYP3A4 drug metabolism activity supporting physiologically relevant PK/PD studies.
Cell source
Primary (Human Intestinal Biopsy-Derived Organoid Cells)
Application
Drug Absorption & Metabolism
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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